Sources of Aging

Nu Skin is taking the science of anti-aging to a completely new level by studying the genetic origins of how and why we age. Developed by Nu Skin in collaboration with leading scientists, ageLOC science is based on the discovery of internal sources of aging that contribute to an aging appearance, what Nu Skin calls age-related super markers, or arSuperMarkers. Nu Skin’s exclusive ageLOC science targets these arSuperMarkers—the ultimate sources of aging that can influence how we age.

Based on this discovery, Nu Skin is able to identify critical arSuperMarkers called Youth Gene Clusters, which are functional groups of genes that regulate how we appear to age. Only ageLOC’s proprietary science understands how to reset these Youth Gene Clusters to their youthful patterns of activity. This revolutionary discovery is based upon Nu Skin’s exclusive collaborations with leading scientists around the globe, millions of dollars in development, and years of combined anti-aging and genetic research.


DNA Heatmap

Nuskin ageLOC Science – Partner Life Gen Technologies

Identifying the Source

The scientific community has access to the Human Genome, but Nu Skin’s breakthrough ageLOC science gives us the ability to interpret it in a meaningful way. In a recent scientific discovery, Nu Skin, in collaboration with anti-aging and genetics experts, has identified key groups or functional clusters of genes—Youth Gene Clusters—that help influence how we age. Nu Skin believes that finding and identifying these functional groups of genes is the key to addressing aging at the source.

Clinical study results, genomic analyses, and substantiated research from ageLOC science has led Nu Skin scientists to identify specific functional Youth Gene Clusters that are responsible for youthful skin attributes. The expression of these genes is responsible for the signs of aging on our skin. Through ageLOC science, Nu Skin has the ability to reset these genes to behave more youthfully, helping to restore a more youthful balance in the skin.

Resetting the Balance

Once we identify these Youth Gene Clusters, it’s important to reset them to reflect a more youthful skin profile. Resetting Youth Gene Clusters is a subtle balancing process—it’s not as simple as turning them on and off. Some genes within the cluster may need to be turned up while others may need to be turned down. Nu Skin’s proprietary ageLOC science resets Youth Gene Clusters to create a youthful balance within each cluster—returning them to their youthful patterns of activity.

Download Documents

ageLOC Product Brochure
ageLOC Science Brochure

Our Science

Innovative Proprietary Collaborative

Scientific innovation has established Nu Skin as a leader in the nutritional and personal care industries. Our proprietary product formulations and technologies enable us to set new industry standards in anti-aging, with real solutions that exhibit demonstrable results. Our team of in-house scientists located in three global research centers demonstrates our commitment to research and development by collaborating with multiple leading research institutions. These collaborative relationships help us develop next-generation skin care and nutritional products with an enhanced understanding of the genetic basis of aging.

With this understanding, Nu Skin has developed the science to go beyond the symptoms of aging to target the ultimate sources of aging. This innovative approach is the result of years of unparalleled research in skin and nutritional science combined with some of the greatest minds in the scientific world. We are revolutionizing the health and beauty industries with products that offer comprehensive anti-aging solutions.

ageLOC Science

ageLOC Science

Nu Skin brings together a world-class team of scientists whose pioneering research and insights have changed how the world understands aging. Their work details the genetic basis of aging while demonstrating that biological aging is no longer considered an inexorable or inevitable process. Building on these insights, Nu Skin developed ageLOC science.

Through ageLOC science, Nu Skin has the ability to go beyond the symptoms of aging to target the ultimate sources of aging. Nu Skin and our collaborators are focusing on identifying the ultimate sources of aging called “age related super markers” or arSuperMarkers. Nu Skin’s first arSuperMarker, arNOX, is an age-related ECTO-NOX protein found on the cell surface that is capable of superoxide generation.

Nu Skin next identified groups of genes that play a central role in the aging process, key arSuperMarkers called Youth Gene Clusters (YGCs). Using proprietary ageLOC science and ingredients, we have found ways to reset these YGCs to reflect a more youthful profile.

ageLOC science is not dependent on any single discovery or scientific paper. This innovative approach is the result of years of unparalleled research in skin and nutritional science combined with some of the greatest minds in the scientific world. Our Nu Skin research and development scientists have incorporated key learnings from leading genetic researchers and anti-aging specialists. Our knowledge and understanding of these learnings are then applied in the development of proprietary, innovative, safe, and effective products. We are revolutionizing the nutrition and personal care industries with products that offer comprehensive anti-aging solutions.

We believe that over the next five to 10 years as the ageLOC scientific approach matures, its full impact will be realized in many ways, including both topical and ingestible applications. The ageLOC scientific approach provides Nu Skin with the technology to further enhance our tradition of innovation. It’s an exciting time for Nu Skin science!

There are several patents associated with our ageLOC science, ingredients, and products. While ageLOC research and development continue, this groundbreaking research has already led to 16 patents or patents pending.

The Basis of ageLOC Science Compendium
ageLOC Science: The Genetics of Youth Compendium
Anti-Aging Medical News Article Reprint—”Nutritional and Genetic Strategies for Longevity,” by Mark Bartlett, Ph.D.
2010 ageLOC Science Year in Review

Personal Care Science

Nu Skin is a leader in the personal care industry with scientifically advanced anti-aging ingredient technologies and skin beneficial formulas comprised of only the best ingredients.

Articles of Interest
Science Downloads and Resources

Nutritionals Science

By applying pharmaceutical science techniques to nature’s remedies, Nu Skin has become a leader in the anti-aging health care industry, providing nutritional supplements under the Pharmanex brand.

Articles of Interest

The Future of Anti-Aging

“We begin the next 25 years with great momentum. At a time when increasing numbers of people are seeking economic security, our strategy is to provide a focused, innovative, and compelling business opportunity, with particular emphasis on our anti-aging product platform and distributor compensation.

As we usher in the next 25 years, we’ll continue to be a beacon of innovation and integrity, setting the standard for others to follow as we demonstrate our difference through our people, product, opportunity, and culture.”
– Truman Hunt, President and Chief Executive Officer

Nu Skin Discovery
Nu Skin has unlocked the science behind the secret to looking and feeling young. Nu Skin’s revolutionary ageLOC platform delivers exclusive solutions that target aging at its very source. By slowing internal sources, ageLOC helps you look, feel, and live younger.

ageLOC Science


I feel like I can have a hundred things coming at me at once
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